The aim of the present study was the development of a â??smart bandageâ? for the\ntopical administration of diclofenac, in the treatment of localized painful and inflammatory\nconditions, incorporating Molecularly Imprinted Polymers (MIPs) for the controlled release of this\nanti-inflammatory drug. For this purpose, MIP spherical particles were synthesized by precipitation\npolymerization, loaded with the therapeutic agent and incorporated into the bandage surface. Batch\nadsorption binding studies were performed to investigate the adsorption isotherms and kinetics\nand the selective recognition abilities of the synthesized MIP. In vitro diffusion studies were also\ncarried out using Franz cells and the obtained results were reported as percentage of the diffused\ndose, cumulative amount of diffused drug, steady-state drug flux and permeability coefficient.\nMoreover, the biocompatibility of the developed device was evaluated using the EPISKINâ?¢ model.\nThe Scatchard analysis indicated that the prepared MIP is characterized by the presence of specific\nbinding sites for diclofenac, which are not present in the corresponding non-imprinted polymer, and\nthe obtained results confirmed both the ability of the prepared bandage to prolong the drug release\nand the absence of skin irritation reactions. Therefore, these results support the potential application\nof the developed â??smart bandageâ? as topical device for diclofenac sustained release.
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